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Resume of Sensory Physiology Research Projects

Neural coding of moving sound sources

Funding:

• Sensitivity to dynamic interaural intensity differences of cells in cat auditory midbrain." National Health and Medical Research Council, 1994 - 1996, $23,181.
• The role of adaptation in shaping responses to a cue for sound source motion in cells of the primary auditory midbrain. Australian Research Council Grant, 1994, $5,000.
• Processing of cues to simulated sound source motion: the study of sensitivity to dynamic interaural intensity differences of cells in the primary auditory midbrain of the cat." Australian Research Council Grant, 1993, $6,135.
• Processing of cues to simulated sound source motion: the study of sensitivity to dynamic interaural intensity differences of cells in the primary auditory midbrain of the cat." Australian Research Council Grant, 1992, $11,500.
• Neural mechanisms underlying the identification of a single sound source in a noisy acoustic environment." Monash Research Fund, 1990, $5000.

• Stephan, K.L. *Wise L.Z., Rajan, R. and Siu, M.K. (1997) The role of excitatory and inhibitory adaptation in encoding dynamic interaural level differences in the rat inferior colliculus. ARO Abstracts
• Wise, L.Z., Rajan,R., Rogers, G., and Smith, P. (1994) Adaptation and excitatory - inhibitory interactions in inferior colliculus of the rat. Proceedings of the Australian Neuroscience Society,
• Wise, L.Z., Irvine, D.R.F., Smith, A., and Bakker, D. (1993) Responses of cat inferior colliculus neurones to dichotically presented interaural intensity differences. Proceedings of the Australian Neuroscience Society, 4:56.
• Wise, L.Z., Smith, A. and Irvine, D.R.F. (1992) Response characteristics of cat inferior colliculus neurons to dichotically-presented correlates of sound source motion

Plasticity of sound frequency representation in cat auditory cortex

Papers:

• Rajan, R., Irvine, D.R.F., Wise, L.Z. and Heil, P. (1993) The effects of restricted unilateral cochlear lesions on the representation of both cochleae in the primary auditory cortex contralateral to the lesion. Journal of Comparative Neurology, 338: 17-49.
• Rajan, R., Irvine, D.R.F., Calford, M.B. and Wise, L.Z. (1992) Effects of frequency-specific losses in cochlear neural sensitivity on the processing and representation of frequency in primary auditory cortex. In: A.L. Dancer, D. Henderson, R.J. Salvi, and R.P. Hamernik (Eds.) Noise-induced hearing loss. Chicago: B.C. Moseby-Year Book.

• Irvine, D.R.F., Rajan,R., Wise, L.Z. and Heil, P. (1991) Reorganisation in auditory cortex of adult cats with unilateral restricted cochlear lesions. Society for Neuroscience Abstracts, 17:1485.
• Irvine, D.R.F., Rajan, R. and Wise, L.Z. (1990) Effects of restricted unilateral cochlear lesions in adult cats on representation of the lesioned and normal cochleas in primary auditory cortex contralateral to the lesioned ear. Proceedings of the Australian Neuroscience Society, 1:90.
• Rajan, R., Irvine, D.R.F., Calford, M.B. and Wise, L.Z. (1990) Effect of losses in cochlear neural sensitivities on the tonotopic organisation and frequency sensitivity in primary auditory cortex. Proceedings of the IVth International conference on effects of noise on the auditory system. Beaune, France.

Comparative neurophysiological and electrical stimulation studies of avian midbrain

I continued my avian work with Prof. Wallman and his colleagues in New York, and Prof. Frost and his students in Canada. During my year in New York, I established in the lab procedures for making tungsten microelectrodes, and I learnt a number of techniques for measuring eye movements, and for working with avian species.

I went to Canada to help establish an auditory laboratory for Prof. Frost to complement his visual research program. In my three years in Canada, my responsibility was to ensure that the auditory laboratory was functioning appropriately, and to guide the development of appropriate software to generate stimuli and record data.

Papers:

• Frost, B.J., Wise, L.Z., Morgan, B. and Bird, D. (1990) Retinotopic representation of the bifoveate eye of the kestrel (Falco Sparverius) on the optic tectum. Visual Neuroscience, 5:231-239.
• Calford, M.B, Wise, L.Z. and Pettigrew, J.D. (1985) Coding of sound location and frequency in the auditory midbrain of diurnal birds of prey, families Accipitridae and Falconidae. Journal of Comparative Physiology, 157:149-160.

• Wise, L.Z., Frost, B.J. and Shaver, S.W. (1989) Frequency representation and spatial organisation in the midbrain of the saw whet owl (Aegolius acadicus). Proceedings of the Robertson Symposium.
• Wise, L.Z., Frost, B.J. and Shaver, S.W. (1988) The representation of sound frequency and space in the midbrain of the saw-whet owl (Aegolius acadicus). Society for Neuroscience Abstracts,2:1095
• Frost, B.J., Morgan, B., Wise, L.Z. and Bird, D. (1987) Retinotopic representation upon the optic tectum of the bifoveate kestrel (Falco sparverius). Association for Research into Vision and Ophthalmology Abstracts,124.
• Shaver, S., Wise, L.Z. and Frost, B.J. (1987) Frequency organisation in the midbrain of the bobwhite quail (Colinus virginianus). Society for Neuroscience Abstracts, 1:543.
• Wise, L.Z., Letelier, J-C. and Wallman, J.W. (1986) Eye movements elicited by microstimulation of chicken optic tectum. Society for Neuroscience Abstracts, 2:1185
.
• Calford, M.B, Wise, L.Z. and Pettigrew, J.D. (1985) Peripheral constraints on the coding of sound in the avian auditory system. Neuroscience Letters,Suppl. 19:S47.

Comparative studies of somatosensory cortical representation in Mega- and Micro-chiropteran bats

Papers:

• Wise, L.Z., Pettigrew, J.D. and Calford, M.B. (1986) Somatosensory cortical representation in the Australian ghost bat, Macroderma gigas. Journal of Comparative Neurology, 248:257-262.
• Calford, M.B, Wise, L.Z. and Pettigrew, J.D. (1985) Audiogram of the grey-headed flying fox (Megachiropteran Pteropidae). Australian Mammalogy, 8:309-312.

• Calford, M.B., Wise, L.Z. and Pettigrew, J.D. (1985) Plasticity of somatosensory cortex in normal adult flying fox. Proceedings of the Australian Physiological and Pharmacological Society, 16:S168.
• Wise, L.Z., Calford, M.B. and Pettigrew, J.D. (1985) Frequency organisation of auditory cortical fields in the flying fox. Neuroscience Letters,Suppl. 19:S111.

Neurophysiological studies of auditory response properties of neurons in deep layers of mammalian superior colliculus

PhD Thesis

• Wise, L.Z. Binaural response properties and sensitivity to interaural intensity differences: topographic organisation in the deep layers of cat superior colliculus. Ph.D. Thesis, Department of Psychology, Monash University, 1984.

• Wise, L.Z. and Irvine, D.R.F. (1985) Topographic organisation of interaural intensity difference sensitivity in the deep layers of cat superior colliculus: implications for auditory spatial representation. Journal of Neurophysiology, 54:185-211.
• Aitkin, L.M., Pettigrew, J.D., Calford, M.B., Phillips, S.C. and Wise, L.Z. (1985) Representation of stimulus azimuth by low- frequency neurons in the inferior colliculus of the cat. Journal of Neurophysiology, 53:43-59.
• Wise, L.Z. and Irvine, D.R.F. (1984) Interaural intensity difference sensitivity based on facilitatory binaural interactions in cat superior colliculus. Hearing Research, 16:181-187.
• Wise, L.Z. and Irvine, D.R.F. (1983) Auditory response properties of neurons in deep layers of cat superior colliculus. Journal of Neurophysiology, 49:674-685.

• Wise, L.Z. and Irvine, D.R.F. (1983) Binaural response properties and sensitivity to interaural intensity differences in cat deep superior colliculus. In: W.R. Webster and L.M. Aitkin (Eds) Mechanisms of Hearing, Clayton, Victoria: Monash University Press, pp 101-106.
• Wise, L.Z. and Irvine, D.R.F. (1983) Topographic organisation of interaural-intensity-difference sensitivity in deep superior colliculus. Journal of the Acoustical Society of America, 73:Suppl. 1:S61.
• Wise, L.Z., Irvine, D.R.F., Pettigrew, J.D. and Calford, M.B. (1982) Auditory spatial receptive field properties of neurons in intermediate and deep layers of cat superior colliculus. Neuroscience Letters, Suppl. 8:S88.
• Wise, L.Z. and Irvine, D.R.F. (1981) Auditory response properties of neurons in the intermediate and deep layers of cat superior colliculus. Proceedings of the Australian Physiological and Pharmacological Society, 12:18P.